Sister with lipoatrophy
Aug 30, 2011
i had written to you before about a sister who's been HIV+ for the past 9yrs but my question hasn't been answered for 3days now.the problem is shes losing a lot of weight which includes facial wasting. what makes matters worst is that there are veins all over her arms and legs this makes it so evident that she's sick and this makes her lose her self esteem.would you advise for a change of regimen or should she stop?because she'd stopped sometime ago for about 2wks and there was improvement.she takes a combination of nevirapine, zidovudine and tenovir. i really would like to help my sister. plz help Dr.
Response from Dr. Pierone
Your sister has a combination of facial wasting and subcutaneous fat wasting that characterizes a condition known as lipoatrophy.
The HIV combination treatment that your sister takes contains 3 different antiretrovirals. Nevirapine is a NNRTI non-nuclesoside reverse transcriptase inhibitor that has not been linked with lipoatrophy. Tenofovir is a nucleotide reverse transcriptase inhibitor that is linked to lipoatrophy, but confers a lower risk than other "nukes". Zidovudine (AZT, Retrovir) is a thymidine analogue nucleoside reverse transcriptase inhibitor that contributes to the development of lipoatrophy.
Changing zidovudine to an alternative agent may help reverse the lipoatrophy that your sister is experiencing. One option would be a switch from zidovudine to the integrase inhibitor raltegravir (Isentress).
I hope this information helps and best of luck!
Get Email Notifications When This Forum Updates or Subscribe With RSS
- Why Cant I Get Rid Of Bacterial Vaginosis?
- What Is The Chlamydia And Gonorrhea Test Called?
- What Does It Mean If You Have Negative Herpes Antibodies?
- What Are The Chances Of Passing Chlamydia With A Condom?
- Ways To Contract Chlamydia
- Took Antibiotics As Prescribed For Chlamydia And Still Have Symptoms
This forum is designed for educational purposes only, and experts are not rendering medical, mental health, legal or other professional advice or services. If you have or suspect you may have a medical, mental health, legal or other problem that requires advice, consult your own caregiver, attorney or other qualified professional.
Experts appearing on this page are independent and are solely responsible for editing and fact-checking their material. Neither TheBody.com nor any advertiser is the publisher or speaker of posted visitors' questions or the experts' material.