|atripla or truvada/isentress ?
Mar 30, 2010
Dr, im gonna to start soon with med, my DR, wants to choose one HAART, Which one is less associated with facial and body wasting? thanks
| Response from Dr. Pierone
At the recent Retrovirus meeting in San Francisco there was a presentation by Dr. Edwin DeJesus on a comparison of metabolic changes between Atripla and Isentress/Truvada. At 96 weeks of follow up no significant differences between these regimens were observed. As a whole, patients in both groups had increased limb fat at 96 weeks compared with baseline.
However, 5 of the 75 patients in this metabolic substudy did meet criteria for lipoatrophy with a decline of 20 percent of limb fat (3 in the Isentress group and 2 in the Atripla group).
So at 2 years the overall trend is for increased limb fat, but some individuals do develop lipoatrophy.
One additional point was that cholesterol and triglyceride levels were lower in the Isentress/Truvada group.
I hope that this information helps and best of luck to you!
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