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lowest potential meds for lipo side effects
Dec 1, 2009

I'm soon to start meds and would like to know what meds, or combos, carry the least risk of lipo. Atripla? Isentress and Truvada or Isentress and Epzicom. This is very hard to figure out.

Response from Dr. Pierone

This is hard to figure this out because of a lack of hard data in head to head comparative trials that measure lipoatrophy outcomes.

But from extrapolation from the available studies, it seems the combination with the least risk of metabolic side effects is Truvada and Isentress.

The Sustiva (efavirenz) in Atripla tends to raise cholesterol, may cause gynecomastia, and generally has more side effects than Isentress. Epzicom increases the risk of heart attacks and occasionally produces a fatal hypersensitivity reaction; so it has been relegated to second tier status.

Good luck!



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