|New meds not linked to lipo
May 5, 2009
What are the new drugs not linked with problems of lipoatrophy? How many drugs are in development without this problem? How long it will take to bring them to the market?
| Response from Dr. Pierone
The new protease inhibitors (and old as well) appear to confer less risk of lipoatrophy and probably are somewhat protective against development of lipoatrophy as well. However, protease inhibitors also carry a greater risk of lipohypertrophy, hyperlipidemia, diabetes mellitus and myocardial infarction.
Thus far, Isentress (raltegravir), the new integrase inhibitor, appears to have a low risk of lipoatrophy, but it has not been on the market very long. The same statement can be said for Intelence (etravirine). With regard to agents in the pipeline, it is way too early to tell. It actually took quite a few years after its release for clinicians to realize that d4T (Zerit) was causing lipoatrophy. So we really will not have this problem sorted out properly for a number of years.
Thanks for posting and good luck!
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