Lipoatrophy from Truvada Norvir Reyataz?
Apr 1, 2009
I am taking Reyataz, Norvir and Truvada for 20 months. I found out I was positive and think I could have been so only around 9 months before knowing. My CD4 was 300-350 and went on meds I stated before a month later. I eat well, and live as I always have, a healthy life. I wanted to know your experience with Wasting/Lipoatrophy on this regimen. Is there a regimen that is better to avoid wasting/lipoatrophy?Does every regimen eventually cause Wasting/Lipoatrophy? thanks
Response from Dr. Pierone
Hello, and thanks for posting.
Truvada is the least likely of the nucleosides to produce lipoatrophy. Also, it is likely that Norvir and Reyataz may provide some partial protection against lipoatrophy because of the tendency for boosted protease inhibitors to produce some weight gain.
Lipoatrophy is not an inevitable consequence of antiretroviral treatment and some patients are fine after many years of older more toxic medications.
Some of the newer medications like raltegravir (Isentress) may be even less likely to produce lipoatrophy, although this remains to be proven.
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