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Drug resistance and lypodystrophy

Jan 20, 2005

With resistance to combivir and stoctrin, my doctor put me on a viracept, Norvir, videx and zerit combination. So far it has been okay except for a very low cd4 which is not improving (107). However, I have started experiencing lypoastrophy/dystrophy, loosing fat in limbs, face and buttocks. I wonder if fuzeon has a propensity to cause lypo?

Response from Mr. Kurtyka

I am not aware of any data that indicates that Fuzeon directly contributes to lipoatrophy/lipodystrophy. The group of drugs most commonly believed to be involved in the lipoatrophy process are the nucleoside reverse transcriptase inhibitors (NRTIs), most notably stavudine (Zerit). In looking at your antiretroviral regimen, I suspect the Zerit and Videx are probably contributing most to your lipoatrophy.


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