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Ask the Experts about Facial Wasting
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lypodystrophy from Ziagen?
Jul 27, 2008

does ziagen cause lypodystrophy and or facial wasting ?

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   Response from Dr. Pierone

Hello and thanks for posting.

As a class, all nucleoside reverse transcriptase inhibitors may produce mitochondrial toxicity and lipodystrophy to varying degrees. Ziagen (abacavir) appears to be in the middle of the pack in this regard. It is less likely to produce problems compared with AZT and d4T, but may contribute to this complication.



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