Nov 16, 2001
Doctors, Of the two PI's, ritonavir and nelfinavir, recomended for treatment in HIV infected infants, which one is better tolerated with the least amount of potential side effects? Is there another PI that you would recommend to take with AZT and 3TC that is equally or better tolerated for infants? Thank you ahead for your response.
Response from Dr. Luzuriaga
Nelfinavir and ritonavir are the 2 PI's for which we have the best pharmacokinetic and safety data across the age spectrum in pediatrics. We have very sparse data on the pk and safety of the other PI's in young infants. In general, nelfinavir is more palatable than ritonavir and thus is more widely used. Another reason that we often like to begin with nelfinavir is that the most common resistance mutation associated with nelfinavir (D30N) does not necessarily confer cross-resistance to other PI's. Both have excellent safety profiles in young infants.
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