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infant testing with non b clade virus
Jun 28, 2001

we are seeing more infants born to women with non b clade virus and want to do the appropriate diagnostic testing on the infants. how do you perform diagnostic testing for those infants. one approach that we have been talking about is to do the DNA PCR on the moms, and if it works then do it on the baby. also what kind of diagnostic testing should we do for infants that have been internationally adopted and we don't know what clade of virus the mother could potentially have. thanks very much. barbara cuene

Response from Dr. Jackson

If the baby is not on antiretrovirals after birth (which is often the case in devloping countries), then I suggest testing for plasma HIV RNA using one of the commercially available kits which detect non-B subtypes such as the Roche 1.5 Amplicor kit or the Organon-Teknika Nuclisens assay. If the baby is on antiretrovirals, DNA PCR may be more sensitive. Your idea of testing the mother first may be a good one if you use an assay that misses some non-B subtypes. On the other hand the mother's DNA viral load may be higher so that even though viral DNA can be detected in the mother, it might not be in the baby. HIV culture of PBMCs is the other option.

BJ


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