|Hydroxyurea & children
Feb 7, 2001
Is Hydroxyurea now being given to pediatric patients? If so, please tell me is this still experimental?
Response from Dr. Luzuriaga
Hydroxyurea has been used in children, but there are few formal studies. A pilot study of hydroxyurea in combination with stavudine and ddI has recently been published (Kline et al, Pilot study of hydroxyurea in human immunodeficiency virus-infected children receiving didanosine and/or stavudine. Pediatr Infect Dis J 2000 19:1083-6). In this small study, they found that doses up to 30 mg/kg/day were fairly well-tolerated but low white blood counts were seen in some children. Modest reductions in viral load were seen in some children. So, data on hydroxyurea in children are rather sparse and the potential risks/benefits of using hydroxyrea in children remain unclear.
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