I have oral KS, and all down my esophagus. I now have a lesion growing in the back of the mouth, near the throat. I can no longer swallow large pills.

I'm afraid it will continue to grow and block my airways or at the least, my ability to swallow.

I started chemo last week using Doxil and go every three weeks.

Could the lesion be removed surgically, or should I just wait for the chemo to hopefully work. No one has given me a "timetable" of when to expect milestones.

Given the extent of your KS, you need chemotherapy. I'm pleased to see that this is exactly what you are receiving. Doxil is a liposomal type of chemotherapy. Its liposomal formulation enables the drug to accumulate in the KS lesions and spare your vital organs. It works quite well and I imagine you'll do well. Doxil (and DaunoXome- a similar drug) work best if you are on anti-retroviral medications.

In terms of surgery, forget it. Surgery rarely helps KS. Sometimes after surgery, KS can regrow at the scar site. I wouldn't recommend it. Stick with the chemotherapy for a while. I typically treat my patients with 6 cycles of treatment; some need more, some need less depending on the circumstances. Good Luck.