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Change in Profile?
Nov 24, 2002

Dear Dr. Holodniy, just a question, in my first Western_Blot test I was positive to 6 antigens, this was 20 years ago, in a recent WB I am Poz to 3, GP 120, 160 and 41, what does this change means? Thanks for your patience.

Response from Dr. Holodniy

Not sure what it means. Those are all HIV envelop antigens. There is not alot of data looking at people in your situation, with long term infection, where we have done followup western blot tests. Not knowing your clinical situation, it is also hard to speculate. Some people with very advanced disease, lose their capacity to make HIV antibodies (that has been described). On the other extreme, people who are long-term nonprogressors, with little detectable viral replication, or people on long-term HIV treatment also without ongoing viral replication, might not have enough antigen stimulation to have continued antibody production.


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