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brain barrier
Jul 29, 2008

Dr. Moyle,

I have been on Norvir,Lexiva,and Truvada for several yrs. with good results. However, do these meds cross the brain barrier. If not. Is the any real concern for brain illnesses? IN FLORIDA.

Response from Dr. Moyle

The components of truvada certainly cross the brain barrier. Its less clear with PIs like lexiva. As a general rule, when the plasma viral load is undetectable, the fluid around the brain (CSF) also shows an undetectable viral load. This does not mean no viral activity but over the last 10 years dementia in people with HIV (without other cause except HIV)as essentially vanished. So you should have no concerns Best Wishes Dr Moyle



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